产品名称
SPC24 Rabbit Polyclonal Antibody
蛋白名称
Kinetochore protein Spc24 (hSpc24)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=147841
Human Swissprot No.
Q8NBT2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NBT2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67629
Mouse Swissprot No.
Q9D083
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D083/entry
特异性
This antibody detects endogenous levels of SPC24 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Chromosome, centromere, kinetochore . Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. .
功能
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules .
