产品名称
RAP2A Rabbit Polyclonal Antibody
蛋白名称
Ras-related protein Rap-2a (RbBP-30)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5911
Human Swissprot No.
P10114
Human Swissprot Link
https://www.uniprot.org/uniprot/P10114
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76108
Mouse Swissprot No.
Q80ZJ1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80ZJ1/entry
特异性
This antibody detects endogenous levels of RAP2A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443). .
功能
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
