产品名称
HSD17B3 Rabbit Polyclonal Antibody
蛋白名称
Testosterone 17-beta-dehydrogenase 3 (EC 1.1.1.64) (17-beta-hydroxysteroid dehydrogenase type 3) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3293
Human Swissprot No.
P37058
Human Swissprot Link
https://www.uniprot.org/uniprot/P37058
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15487
Mouse Swissprot No.
P70385
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70385/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117182
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O54939/entry
特异性
This antibody detects endogenous levels of HSD17B3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum .
功能
Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids . Favors the reduction of androstenedione to testosterone . Testosterone is the key androgen driving male development and function . Uses NADPH while the two other EDH17B enzymes use NADH . Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 . Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms .
