产品名称
EB1 Rabbit Polyclonal Antibody
蛋白名称
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22919
Human Swissprot No.
Q15691
Human Swissprot Link
https://www.uniprot.org/uniprot/Q15691
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13589
Mouse Swissprot No.
Q61166
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61166/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114764
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q66HR2/entry
特异性
This antibody detects endogenous levels of EB1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Golgi apparatus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Associated with the microtubule growing distal tips (PubMed:28814570). Recruitment to the Golgi apparatus requires the presence of PDE4DIP isoform 13/MMG8/SMYLE (PubMed:25217626). .
功能
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton . Promotes cytoplasmic microtubule nucleation and elongation . Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation . Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement . Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules . Acts as a regulator of autophagosome transport via interaction with CAMSAP2 . May play a role in cell migration (By similarity).
