产品名称
TIMM8A Rabbit Polyclonal Antibody
基因名称
TIMM8A DDP DDP1 TIM8A
蛋白名称
Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1678
Human Swissprot No.
O60220
Human Swissprot Link
https://www.uniprot.org/uniprot/O60220
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30058
Mouse Swissprot No.
Q9WVA2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WVA2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84383
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WVA1/entry
特异性
This antibody detects endogenous levels of TIMM8A at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in fetal and adult brain, followed by fetal lung, liver and kidney. Also expressed in heart, placenta, lung, liver, kidney, pancreas, skeletal muscle and heart.
细胞定位
Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side .
功能
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.
