产品名称
PDE8A Rabbit Polyclonal Antibody
蛋白名称
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5151
Human Swissprot No.
O60658
Human Swissprot Link
https://www.uniprot.org/uniprot/O60658
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18584
Mouse Swissprot No.
O88502
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88502/entry
特异性
This antibody detects endogenous levels of PDE8A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
功能
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes . May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development . Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling . Protects against cell death induced by hydrogen peroxide and staurosporine .
