产品名称
FMO5 Rabbit Polyclonal Antibody
蛋白名称
Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2330
Human Swissprot No.
P49326
Human Swissprot Link
https://www.uniprot.org/uniprot/P49326
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14263
Mouse Swissprot No.
P97872
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97872/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246248
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K4C0/entry
特异性
This antibody detects endogenous levels of FMO5 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in fetal and adult liver.
细胞定位
Microsome membrane . Endoplasmic reticulum membrane.
功能
Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters . Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive . In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) . Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline . Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity . Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity).
