产品名称
RAB23 Rabbit Polyclonal Antibody
蛋白名称
Ras-related protein Rab-23
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9ULC3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ULC3/entry
Mouse Swissprot No.
P35288
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P35288
免疫原
Synthesized peptide derived from human protein . at AA range: 120-200
特异性
RAB23 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Brain,Fetal brain,Hair follicle,Umbilical cord blood,Uterus,
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm . Cytoplasmic vesicle, autophagosome . Endosome membrane . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Recruited to phagosomes containing S.aureus or M.tuberculosis. .
功能
disease:Defects in RAB23 are the cause of Carpenter syndrome [MIM:201000]; also known as acrocephalopolysyndactyly type 2 (ACPS2). Carpenter syndrome is characterized by craniosynostosis, polysyndactyly, obesity, and cardiac defects. Inheritance is autosomal recessive.,similarity:Belongs to the small GTPase superfamily. Rab family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
