产品名称
FAM49B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51571
Human Swissprot No.
Q9NUQ9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NUQ9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=223601
Mouse Swissprot No.
Q921M7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q921M7/entry
特异性
This antibody detects endogenous levels of FAM49B at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Membrane ; Lipid-anchor . Mitochondrion .
功能
Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling . Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization . Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry . Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress .
