产品名称
NELF-A Rabbit Polyclonal Antibody
基因名称
WHSC2 NELFA P/OKcl.15
蛋白名称
Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7469
Human Swissprot No.
Q9H3P2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H3P2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24116
Mouse Swissprot No.
Q8BG30
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BG30/entry
特异性
This antibody detects endogenous levels of NELF-A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney.
功能
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. ; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
