产品名称
Oligophrenin 1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4983
Human Swissprot No.
O60890
Human Swissprot Link
https://www.uniprot.org/uniprot/O60890
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94190
Mouse Swissprot No.
Q99J31
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99J31/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=312108
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P0CAX5/entry
特异性
This antibody detects endogenous levels of Oligophrenin 1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse . Cell projection, axon . Cell projection, dendritic spine . Cell projection, dendrite . Cytoplasm .
功能
Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity).
