产品名称
MYDGF Rabbit Polyclonal Antibody
蛋白名称
UPF0556 protein C19orf10 (Interleukin-25) (IL-25) (Stromal cell-derived growth factor SF20)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56005
Human Swissprot No.
Q969H8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q969H8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28106
Mouse Swissprot No.
Q9CPT4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CPT4/entry
特异性
This antibody detects endogenous levels of MYDGF at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in eosinophils (at protein level) (PubMed:29954947). Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).
细胞定位
Secreted . Endoplasmic reticulum-Golgi intermediate compartment . Endoplasmic reticulum . Golgi apparatus . The C-terminal RTEL motif may provide retention in the endoplasmic reticulum. .
功能
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis .
