产品名称
TMED2 Rabbit Polyclonal Antibody
蛋白名称
Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10959
Human Swissprot No.
Q15363
Human Swissprot Link
https://www.uniprot.org/uniprot/Q15363
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56334
Mouse Swissprot No.
Q9R0Q3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R0Q3/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65165
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63524/entry
特异性
This antibody detects endogenous levels of TMED2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, COPI-coated vesicle membrane ; Single-pass type I membrane protein . Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein . Golgi apparatus, Golgi stack membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein . Cycles between compartments of the early secretatory pathway. .
功能
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.
