产品名称
SMPDL3B Rabbit Polyclonal Antibody
蛋白名称
Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27293
Human Swissprot No.
Q92485
Human Swissprot Link
https://www.uniprot.org/uniprot/Q92485
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100340
Mouse Swissprot No.
P58242
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P58242/entry
特异性
This antibody detects endogenous levels of SMPDL3B at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Secreted . Cell membrane ; Lipid-anchor, GPI-anchor .
功能
Lipid-modulating phosphodiesterase . Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown . Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).
