产品名称
TRAF3IP2 Rabbit Polyclonal Antibody
基因名称
TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6
蛋白名称
Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10758
Human Swissprot No.
O43734
Human Swissprot Link
https://www.uniprot.org/uniprot/O43734
特异性
This antibody detects endogenous levels of TRAF3IP2 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling . Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein . Essential adapter molecule in IL17A-mediated signaling . Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways .
