产品名称
SMC5 Rabbit Polyclonal Antibody
基因名称
SMC5 KIAA0594 SMC5L1
蛋白名称
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23137
Human Swissprot No.
Q8IY18
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IY18
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=226026
Mouse Swissprot No.
Q8CG46
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CG46/entry
特异性
This antibody detects endogenous levels of SMC5 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570).
细胞定位
Nucleus . Chromosome . Nucleus, PML body . Chromosome, telomere . Associates with chromatin (PubMed:25931565). Colocalizes with SMC6 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). .
功能
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome .
