产品名称
ABCB6 Rabbit Polyclonal Antibody
基因名称
ABCB6 MTABC3 PRP UMAT
蛋白名称
ATP-binding cassette sub-family B member 6, mitochondrial (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10058
Human Swissprot No.
Q9NP58
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NP58
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74104
Mouse Swissprot No.
Q9DC29
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DC29/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140669
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O70595/entry
特异性
This antibody detects endogenous levels of ABCB6 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. High expression is detected in the retinal epithelium (PubMed:10837493, PubMed:22226084). Expressed in mature erythrocytes (PubMed:22655043).
细胞定位
Cell membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Lysosome membrane . Late endosome membrane . Early endosome membrane . Secreted, extracellular exosome . Mitochondrion . Endosome, multivesicular body membrane . Melanosome membrane . Present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation (PubMed:22655043). Traffics from endoplasmic reticulum to Golgi during its glycans's maturation, therefrom is first targeted to the plasma membrane, and is rapidly internalized through endocytosis to be distributed to the limiting membrane of multivesicular bodies and lysosomes (PubMed:25627919, PubMed:21199866, PubMed:18279659). Localized on the limiting membrane of early melanosomes of pigment cells (PubMed:29940187). Targeted to the endolysosomal compartment (By similarity). .
功能
ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen . May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress . May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils . In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin . In addition may play a role in the transition metal homeostasis (By similarity).
