产品名称
Nicastrin Rabbit Polyclonal Antibody
基因名称
NCSTN KIAA0253 UNQ1874/PRO4317
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23385
Human Swissprot No.
Q92542
Human Swissprot Link
https://www.uniprot.org/uniprot/Q92542
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59287
Mouse Swissprot No.
P57716
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P57716/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=289231
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CGU6/entry
特异性
This antibody detects endogenous levels of Nicastrin at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in brain (at protein level) (PubMed:10993067). Widely expressed (PubMed:11396676).
细胞定位
Membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
功能
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
