产品名称
TH1L Rabbit Polyclonal Antibody
基因名称
TH1L NELFD TH1 HSPC130
蛋白名称
Negative elongation factor C/D (NELF-C/D) (TH1-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51497
Human Swissprot No.
Q8IXH7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IXH7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57314
Mouse Swissprot No.
Q922L6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q922L6/entry
特异性
This antibody detects endogenous levels of TH1L at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.
功能
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II . The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex . ; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
