产品名称
MTUS1 Rabbit Polyclonal Antibody
基因名称
MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1
蛋白名称
Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57509
Human Swissprot No.
Q9ULD2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9ULD2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=102103
Mouse Swissprot No.
Q5HZI1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5HZI1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=306487
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6IMY1/entry
特异性
This antibody detects endogenous levels of MTUS1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.
细胞定位
Mitochondrion . Golgi apparatus . Cell membrane . Nucleus . In neurons, translocates into the nucleus after treatment with angiotensin-II. .; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
功能
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
