产品名称
ATAD2 Rabbit Polyclonal Antibody
蛋白名称
ATPase family AAA domain-containing protein 2 (EC 3.6.1.3) (AAA nuclear coregulator cancer-associated protein) (ANCCA)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29028
Human Swissprot No.
Q6PL18
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6PL18
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70472
Mouse Swissprot No.
Q8CDM1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CDM1/entry
特异性
This antibody detects endogenous levels of ATAD2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.
功能
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
