产品名称
SORBS1 Rabbit Polyclonal Antibody
基因名称
SORBS1 KIAA0894 KIAA1296 SH3D5
蛋白名称
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10580
Human Swissprot No.
Q9BX66
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BX66
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20411
Mouse Swissprot No.
Q62417
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q62417/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P84109/entry
特异性
This antibody detects endogenous levels of SORBS1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.
细胞定位
Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus . Nucleus matrix . Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. .
功能
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
