产品名称
DHX15 Rabbit Polyclonal Antibody
蛋白名称
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1665
Human Swissprot No.
O43143
Human Swissprot Link
https://www.uniprot.org/uniprot/O43143
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13204
Mouse Swissprot No.
O35286
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35286/entry
特异性
This antibody detects endogenous levels of DHX15 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Nucleus, nucleolus .
功能
RNA helicase involved in mRNA processing and antiviral innate immunity . Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA . In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns . Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome . Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) . Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses . The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu . Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity).
