产品名称
PELI1 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 6.3.2.-) (Pellino-related intracellular-signaling molecule)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57162
Human Swissprot No.
Q96FA3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96FA3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67245
Mouse Swissprot No.
Q8C669
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C669/entry
特异性
This antibody detects endogenous levels of PELI1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed at high levels in normal skin but decreased in keratinocytes from toxic epidermal necrolysis (TEN) patients (at protein level).
功能
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation . Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 . Negatively regulates necroptosis by reducing RIPK3 expression . Mediates 'Lys-63'-linked ubiquitination of RIPK1 .
