产品名称
APH1A Rabbit Polyclonal Antibody
基因名称
APH1A PSF CGI-78 UNQ579/PRO1141
蛋白名称
Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51107
Human Swissprot No.
Q96BI3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96BI3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=226548
Mouse Swissprot No.
Q8BVF7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BVF7/entry
特异性
This antibody detects endogenous levels of APH1A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein . Predominantly located in the endoplasmic reticulum and in the cis-Golgi. .
功能
Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) . Required for normal gamma-secretase assembly . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).
