产品名称
TMEM97 Rabbit Polyclonal Antibody
蛋白名称
Transmembrane protein 97 (Protein MAC30)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27346
Human Swissprot No.
Q5BJF2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5BJF2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69071
Mouse Swissprot No.
Q8VD00
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VD00/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=303330
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U3Y7/entry
特异性
This antibody detects endogenous levels of TMEM97 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells. Highly expressed in various proliferating cancer cells (PubMed:23922215).
细胞定位
Nucleus membrane ; Multi-pass membrane protein . Rough endoplasmic reticulum membrane ; Multi-pass membrane protein . Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated. .
功能
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells . Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation . Under investigation for its potential diagnostic and therapeutic uses . May play a role as a regulator of cellular cholesterol homeostasis . May function as sterol isomerase . May alter the activity of some cytochrome P450 proteins .
