产品名称
WDR18 Rabbit Polyclonal Antibody
蛋白名称
WD repeat-containing protein 18
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57418
Human Swissprot No.
Q9BV38
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BV38
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=216156
Mouse Swissprot No.
Q4VBE8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q4VBE8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=314617
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q499N3/entry
特异性
This antibody detects endogenous levels of WDR18 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm . Dynein axonemal particle . Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. .
功能
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes . Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit . May play a role during development (By similarity).
