产品名称
TMEM41B Rabbit Polyclonal Antibody
蛋白名称
Transmembrane protein 41B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=440026
Human Swissprot No.
Q5BJD5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5BJD5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=233724
Mouse Swissprot No.
Q8K1A5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K1A5/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361626
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5FVN2/entry
特异性
This antibody detects endogenous levels of TMEM41B at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endomembrane system . Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. .; Cytoplasm . (Microbial infection) Upon infection with infection with flaviviruses, diffuse reticular-like pattern to a large cytosolic aggregate that colocalizes with viral non-structural proteins, NS4A (ZIKV) and NS4B (YFV). .
功能
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes . Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine . Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly . In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required . Required for normal motor neuron development (By similarity). ; (Microbial infection) Critical host factor required for infection by human coronviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus . Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles .
