产品名称
FAPP2 Rabbit Polyclonal Antibody
蛋白名称
Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84725
Human Swissprot No.
Q96JA3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96JA3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=231999
Mouse Swissprot No.
Q80W71
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80W71/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=500132
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/D3ZY60/entry
特异性
This antibody detects endogenous levels of FAPP2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in kidney cell lines.
细胞定位
Golgi apparatus, trans-Golgi network membrane . Membrane; Peripheral membrane protein . Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites. .
功能
Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.
