产品名称
SPCS1 Rabbit Polyclonal Antibody
蛋白名称
Signal peptidase complex subunit 1 (EC 3.4.-.-) (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28972
Human Swissprot No.
Q9Y6A9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y6A9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69019
Mouse Swissprot No.
Q9D958
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D958/entry
特异性
This antibody detects endogenous levels of SPCS1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum . Dispensable for SPC enzymatic activity (By similarity). ; (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV) . Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1 . In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2 .
