产品名称
PHF17 Rabbit Polyclonal Antibody
基因名称
PHF17 JADE1 KIAA1807
蛋白名称
Protein Jade-1 (PHD finger protein 17)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79960
Human Swissprot No.
Q6IE81
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6IE81
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=269424
Mouse Swissprot No.
Q6ZPI0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZPI0/entry
特异性
This antibody detects endogenous levels of PHF17 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
细胞定位
Nucleus . Chromosome . Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Localizes to the ciliary transition zone. .
功能
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity . Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation . May also promote acetylation of nucleosomal histone H4 by KAT5 . Promotes apoptosis . May act as a renal tumor suppressor . Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function .
