产品名称
RAC3 Rabbit Polyclonal Antibody
蛋白名称
Ras-related C3 botulinum toxin substrate 3 (p21-Rac3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P60763
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P60763/entry
Mouse Swissprot No.
P60764
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P60764
免疫原
Synthesized peptide derived from human protein . at AA range: 80-160
特异性
RAC3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
组织表达
Highest levels in brain, also detected in heart, placenta and pancreas.
细胞定位
Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;WNT;WNT-T CELLAxon guidance;VEGF;Focal adhesion;Adherens_Junction;Natural killer cell mediated cytotoxicity;B_Cell_Antigen;Fc epsilon RI;Regulates Actin and Cytoskeleton;Pathways in cancer;Colorectal cancer;Pancreatic cancer
功能
function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.,induction:Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia.,subunit:Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D.,tissue specificity:Highest levels in brain, also detected in heart, placenta and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
