产品名称
RAC2 Rabbit Polyclonal Antibody
蛋白名称
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
反应种属
Human,Mouse,Bovine,Bovine
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P15153
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P15153/entry
Mouse Swissprot No.
Q05144
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q05144
免疫原
Synthesized peptide derived from human protein . at AA range: 130-210
特异性
RAC2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013],
组织表达
Hematopoietic specific.
细胞定位
Cytoplasm. Membrane-associated when activated.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Chemokine;WNT;WNT-T CELLAxon guidance;VEGF;Focal adhesion;Adherens_Junction;Natural killer cell mediated cytotoxicity;B_Cell_Antigen;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;Regulat
功能
disease:Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome [MIM:608203].,enzyme regulation:Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.,function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Seems to be involved in the regulation of the NADPH oxidase.,online information:RAC2 mutation db,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated.,subunit:Interacts with DOCK2, which may activate it.,tissue specificity:Hematopoietic specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
