产品名称
NANOS3 Rabbit Polyclonal Antibody
蛋白名称
Nanos homolog 3 (NOS-3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=342977
Human Swissprot No.
P60323
Human Swissprot Link
https://www.uniprot.org/uniprot/P60323
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=244551
Mouse Swissprot No.
P60324
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P60324/entry
特异性
This antibody detects endogenous levels of NANOS3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.
细胞定位
Nucleus . Cytoplasm . Cytoplasm, Stress granule . Cytoplasm, P-body . Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. .
功能
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
