产品名称
CKB/CKM Rabbit Polyclonal Antibody
蛋白名称
Creatine kinase B-type (EC 2.7.3.2) (B-CK) (Creatine kinase B chain)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1152
Human Swissprot No.
P12277
Human Swissprot Link
https://www.uniprot.org/uniprot/P12277
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12709
Mouse Swissprot No.
Q04447
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q04447/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24264
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P07335/entry
特异性
This antibody detects endogenous levels of CKB/CKM at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytosol . Mitochondrion . Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region. .
功能
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) . Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity).
