产品名称
TRIOBP Rabbit Polyclonal Antibody
基因名称
TRIOBP KIAA1662 TARA HRIHFB2122
蛋白名称
TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11078
Human Swissprot No.
Q9H2D6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H2D6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=110253
Mouse Swissprot No.
Q99KW3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99KW3/entry
特异性
This antibody detects endogenous levels of TRIOBP at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.
细胞定位
Nucleus . Cytoplasm, cytoskeleton . Localized to F-actin in a periodic pattern. .; [Isoform 1]: Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody. .
功能
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.
