产品名称
TMEM55B Rabbit Polyclonal Antibody
蛋白名称
Transmembrane protein 55B (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=90809
Human Swissprot No.
Q86T03
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86T03
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=219024
Mouse Swissprot No.
Q3TWL2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TWL2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=364298
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5PPM8/entry
特异性
This antibody detects endogenous levels of TMEM55B at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
功能
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) . Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate . Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules . Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 . May play a role in the regulation of cellular cholesterol metabolism .
