产品名称
IPO7 Rabbit Polyclonal Antibody
蛋白名称
Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10527
Human Swissprot No.
O95373
Human Swissprot Link
https://www.uniprot.org/uniprot/O95373
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=233726
Mouse Swissprot No.
Q9EPL8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPL8/entry
特异性
This antibody detects endogenous levels of IPO7 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. ; (Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev.
