产品名称
LZTS2 Rabbit Polyclonal Antibody
基因名称
LZTS2 KIAA1813 LAPSER1
蛋白名称
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84445
Human Swissprot No.
Q9BRK4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BRK4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=226154
Mouse Swissprot No.
Q91YU6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91YU6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=365468
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q3LUD4/entry
特异性
This antibody detects endogenous levels of LZTS2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
功能
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
