产品名称
ERCC6L Rabbit Polyclonal Antibody
蛋白名称
DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54821
Human Swissprot No.
Q2NKX8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q2NKX8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=236930
Mouse Swissprot No.
Q8BHK9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BHK9/entry
特异性
This antibody detects endogenous levels of ERCC6L at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Chromosome, centromere . Chromosome, centromere, kinetochore . Chromosome . Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. .
功能
DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase . Functions as ATP-dependent DNA translocase . Can promote Holliday junction branch migration (in vitro) .
