产品名称
EHD2 Rabbit Polyclonal Antibody
蛋白名称
EH domain-containing protein 2 (PAST homolog 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30846
Human Swissprot No.
Q9NZN4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NZN4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=259300
Mouse Swissprot No.
Q8BH64
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BH64/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361512
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4V8H8/entry
特异性
This antibody detects endogenous levels of EHD2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle.
细胞定位
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Membrane, caveola ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes. .
功能
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes . Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane .
