产品名称
PQBP1 Rabbit Polyclonal Antibody
蛋白名称
Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10084
Human Swissprot No.
O60828
Human Swissprot Link
https://www.uniprot.org/uniprot/O60828
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54633
Mouse Swissprot No.
Q91VJ5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91VJ5/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=302557
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PCT5/entry
特异性
This antibody detects endogenous levels of PQBP1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes.
细胞定位
Nucleus . Nucleus speckle . Cytoplasmic granule . Colocalizes with SRSF2 in nuclear speckles (By similarity). Colocalized with POU3F2 (PubMed:10332029). Colocalized with ATXN1 in nuclear inclusion bodies (PubMed:12062018). Localizes to cytoplasmic stress granules (PubMed:21933836). .
功能
Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development . Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species . May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery . May be involved in ATXN1 mutant-induced cell death . The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit . Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules . Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol . Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production .
