产品名称
SEC63 Rabbit Polyclonal Antibody
蛋白名称
Translocation protein SEC63 homolog
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11231
Human Swissprot No.
Q9UGP8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UGP8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140740
Mouse Swissprot No.
Q8VHE0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VHE0/entry
特异性
This antibody detects endogenous levels of SEC63 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed, with high levels in the liver.
细胞定位
Endoplasmic reticulum membrane; Multi-pass membrane protein.
功能
Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) . Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen . Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
