BD-PN1157

RASL1 Rabbit Polyclonal Antibody

常规抗体

RASAL1 RASAL

RasGAP-activating-like protein 1

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

8437

O95294

https://www.uniprot.org/uniprotkb/O95294/entry

Q9Z268

http://www.uniprot.org/uniprot/Q9Z268

Synthesized peptide derived from human protein . at AA range: 170-250

RASL1 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

88kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010],

Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea (PubMed:9751798). Expressed in melanocytes (PubMed:23999003).

intracellular,cytosol,plasma membrane,intrinsic component of the cytoplasmic side of the plasma membrane,

function:Probable inhibitory regulator of the Ras-cyclic AMP pathway.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains.,tissue specificity:Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.