产品名称
RNase T2 Rabbit Polyclonal Antibody
蛋白名称
Ribonuclease T2 (EC 3.1.27.-) (Ribonuclease 6)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8635
Human Swissprot No.
O00584
Human Swissprot Link
https://www.uniprot.org/uniprot/O00584
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100037283
Mouse Swissprot No.
Q9CQ01
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQ01/entry
特异性
This antibody detects endogenous levels of RNase T2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
细胞定位
Secreted . Lysosome lumen . Endoplasmic reticulum lumen . Mitochondrion intermembrane space . Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction. .
功能
Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 . Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides . In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 . Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria . Participates as well in degradation of mitochondrion-associated cytosolic rRNAs .
