产品名称
MYH10 Rabbit Polyclonal Antibody
蛋白名称
Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4628
Human Swissprot No.
P35580
Human Swissprot Link
https://www.uniprot.org/uniprot/P35580
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=77579
Mouse Swissprot No.
Q61879
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61879/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79433
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JLT0/entry
特异性
This antibody detects endogenous levels of MYH10 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.
细胞定位
Cell projection, lamellipodium . Colocalizes with MCC at the leading edge of migrating cells.
功能
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.
