产品名称
DBNL Rabbit Polyclonal Antibody
基因名称
DBNL CMAP SH3P7 PP5423
蛋白名称
Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28988
Human Swissprot No.
Q9UJU6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UJU6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13169
Mouse Swissprot No.
Q62418
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q62418/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83527
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JHL4/entry
特异性
This antibody detects endogenous levels of DBNL at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell projection, ruffle . Cytoplasm, cell cortex . Cytoplasm, cytosol . Cell junction, synapse . Perikaryon . Cell projection, neuron projection . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, podosome . Early endosome . Cell projection, dendrite . Cell junction, synapse, postsynaptic density . Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes. .
功能
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
