产品名称
GRP3 Rabbit Polyclonal Antibody
基因名称
RASGRP3 GRP3 KIAA0846
蛋白名称
Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IV61
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IV61/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
GRP3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
RAS guanyl releasing protein 3(RASGRP3) Homo sapiens Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008],
细胞定位
intracellular,plasma membrane,integral component of plasma membrane,guanyl-nucleotide exchange factor complex,perinuclear region of cytoplasm,
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;B_Cell_Antigen;
功能
function:Guanine nucleotide exchange factor (GEF) for Ras and Rap1.,similarity:Belongs to the RASGRP family.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 2 EF-hand domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
