产品名称
Exo70 Rabbit Polyclonal Antibody
基因名称
EXOC7 EXO70 KIAA1067
蛋白名称
Exocyst complex component 7 (Exocyst complex component Exo70)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23265
Human Swissprot No.
Q9UPT5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UPT5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53413
Mouse Swissprot No.
O35250
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35250/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100911734
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O54922/entry
特异性
This antibody detects endogenous levels of Exo70 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Abundant in the ventricular zone, the outer subventricular zone and the cortical plate of the fetal cortex.
细胞定位
Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein . Midbody, Midbody ring . Translocates, as a preformed complex with EXOC3/SEC6 and EXOC4/SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). .
功能
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity).
