产品名称
IQGA2 Rabbit Polyclonal Antibody
蛋白名称
Ras GTPase-activating-like protein IQGAP2
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13576
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13576/entry
Mouse Swissprot No.
Q3UQ44
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UQ44
免疫原
Synthesized peptide derived from human protein . at AA range: 200-280
特异性
IQGA2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
IQ motif containing GTPase activating protein 2(IQGAP2) Homo sapiens This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008],
组织表达
Isoform 2 expression is enhanced in testis.
细胞定位
cytoplasm,cytosol,microtubule,microvillus,cell surface,actin cytoskeleton,lamellipodium,filopodium,filamentous actin,extracellular exosome,
信号通路
Regulates Actin and Cytoskeleton;
功能
function:Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 1 WW domain.,similarity:Contains 3 IQ domains.,tissue specificity:Isoform 2 expression is enhanced in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
